Nucleotide vs Nucleoside – What is the Difference?
These are the two terms we use frequently in molecular biology and we are expected to know it clearly. I knew the structure and assembly of both of them i.e. I knew one is with phosphate and one is without phosphate but the problem was I use to get confused every time which is what đ So, as always I do, I came up with a little trick to remember which is nucleotide and which is nucleoside. Let me first show you the structure and components involved in both and at last I will tell you how I remember it.
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Nucleotide:
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Nucleoside:
Now let me share my trick with you guys. See in nucleotide there is t in the spelling right and it has three components so for me it is t – three, t – three, say it loud while reading it you will know what I am saying, go ahead say it out loud t – three, t – three. So for me in nucleotide t stands for three âşď¸ and since we are talking about three components that means nucleotide is with phosphate. And nucleoside is of course without phosphate. Easy, isnât it!!! Hope it helped. It might sound childish but it really helped me đ
Watch this video for better understanding.